Samenvatting
In 2025 laat het ASz opnieuw een brede en consistente wetenschappelijke productie zien. Met 163 geïndexeerde publicaties bevestigt het ASz zijn positie als topklinisch ziekenhuis met een stevige onderzoeksbasis. In ten minste 29 publicaties stond een ASz-auteur als eerste vermeld.
Interne Geneeskunde, Chirurgie en Neurologie waren in 2025 de grootste bijdragers, met daarbij 15%, 13% en 10% van de totale output.
Bij Interne geneeskunde richten de onderzoekslijnen zich onder meer op hematologische maligniteiten (AML, CLL, CML, lymfoom, multipel myeloom), MRDgestuurde en fixed-duration therapieën, behandeling vrije remissie, innovatieve combinatieschema’s, farmacokinetiek, ondersteunende zorg, cardiovasculaire risicopredictie met AI, geriatrische kwetsbaarheid, immuunhematologie en patiënt-gerapporteerde uitkomsten.
Chirurgie-publicaties richtten zich op chirurgische innovaties en oncologische
Algemeen
PMID: 40752630
Comparison of regional lung mechanics using electrical impedance tomography in mechanically ventilated COVID-19 vs prepandemic patients: A retrospective study. I. van der Horst
PMID: 39994819
Human judgment error in the intensive care unit: a perspective on bias and noise. I. van der Horst
PMID: 40876108
Measuring alarm fatigue in intensive care units: translation and validation of the Charité Alarm Fatigue Questionnaire: a multi-centre study I. van der Horst
PMID: 41243868
Organ Donor Potential After Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest: A PostHoc Analysis of a Randomized Controlled Trial
I. van der Horst uitkomsten bij colorectale, long- en borstkanker, minimaal invasieve technieken, wondgenezing en postoperatieve complicaties, socioeconomische ongelijkheid, AI-gestuurde patiëntinformatie, werkcultuur en veiligheid, traumazorg, tropische infecties en mondiale chirurgische gezondheidszorg.
Neurologie blijft prominent, met aandacht die met name uitgaat naar cerebrovasculaire aandoeningen bij jonge patiënten, MS en andere neuroimmunologische ziekten (MOGAD, NMOSD), biomarkers in bloed en liquor, farmacokinetiek en behandelingseffecten, prehospitale triage, zorgorganisatie, poststroke complicaties, perifere neuropathieën en de darm-hersen-as.
De publicaties in 2025 omvatten een breed spectrum aan studiedesigns, waaronder gerandomiseerde gecontroleerde trials, multicenter noninferiority studies, fase II- en III-onderzoek, populatiegebaseerde cohortstudies, realworld evidence analyses, implementatieonderzoek, diagnostische
PMID: 41063612
Periprocedural Myocardial Infarction After Coronary Artery Bypass Grafting: Current Clinical Practices and Future Perspectives I. van der Horst
PMID: 41239165
Practicalities of noninvasive neuromonitoring in intensive care I. van der Horst
PMID: 41317656
Sex-dependent differences in regional lung mechanics; A retrospective observational study I. van der Horst
Anesthesiologie
PMID: 40397125
[Risk factors and treatment of post-dural puncture headache-an analysis of the German patients of the international EPIMAP study]
A. Schyns-van den Berg
PMID: 40696194
Correction: Association between postpartum depression and chronic postsurgical pain after Cesarean delivery: a secondary accuratesse-studies, prognostische modellering met AI, systematische reviews en meta-analyses, target trial emulatie, translatieonderzoek en fundamenteel biomarker- en biobankonderzoek.
Gezamenlijk laat deze output een evenwicht zien tussen klinisch impactonderzoek, praktijkgericht implementatieonderzoek en innovatie binnen zorgprocessen. Daarmee onderstreept het ASz zijn rol als ziekenhuis waar patiëntenzorg, onderzoek en kwaliteitsverbetering structureel met elkaar verweven zijn. Hieronder tref je een overzicht van de wetenschappelijke publicaties van het ASz. De titels zijn aangeleverd vanuit de Onderzoeksdatabank en de PubMeddatabank. Het publicatieoverzicht en de informatie over lopende studies zijn te vinden op de Bibliotheek- en Wetenschapspagina. Je vindt deze op Intranet. Mis je een artikel, neem dan alsjeblieft contact op met de bibliotheek (bibliotheek@asz.nl) zodat we het artikel kunnen toevoegen.
analysis of a randomized trial A. Schyns-van den Berg
PMID: 39042027
High Positive End-expiratory Pressure (PEEP) with Recruitment Maneuvers versus Low PEEP during General Anesthesia for Surgery: A Bayesian Individual Patient Data Meta-analysis of Three Randomized Clinical Trials L. Posthuma
PMID: 40165340
Performance of the early warning system score in predicting postoperative complications in older versus younger patients L. Posthuma
Anesthesiologie Chirurgie
PMID: 41030844
A care bundle added to standard care versus standard care for the prevention of surgical site infections after abdominal surgery (EPO2CH trial): a randomised, open label, pragmatic, superiority multicentre trial
B. van der Leeuw, J. van der Hoeven
ASz Academie
PMID: 41127554
Understanding Long COVID Among Young People in Victoria, Australia: Prevalence, Impact, and Associated Factors S. van den Toren
PMID: 40010058
Considering health literacy in communication about medications between nurses and patients with heart failure: a cross sectional observational study A. van der Klis
Cardiologie
PMID: 39777867
Contemporary Use of Post-Dilatation for Stent Optimization During Percutaneous Coronary Intervention; Results From the Netherlands Heart Registration J. Cheng
PMID: 40048084
Impact of lesion preparation and stent optimisation on lesion-oriented events in PCI with drug-eluting stents: 5-year results from the AIDA trial
A. Weevers
PMID: 40384053
Comparison of Sirolimus-Versus Paclitaxel-Coated Balloons in Coronary Artery Disease: One-Year Results of Two RealWorld Prospective Registries S. Vlieger, J. Cheng, R. Oemrawsingh
PMID: 40717858
Pain after subcutaneous implantable cardioverter-defibrillator implantation: A secondary analysis of the PRAETORIAN-DFT trial
L. van Woerkens
PMID: 40828313
Changes in non-culprit coronary lesions with PCSK9 inhibitors: the randomised, placebo-controlled FITTER trial R. Oemrawsingh, J. Cheng
Geen PMID
Assessing differential application of thromboprophylaxis regimes related to risk of pulmonary embolism and mortality in COVID-19 patients through instrumental variable analysis D. van de Watering
Geen PMID
Plasma proteomics based sub-phenotypes in coronary artery disease are related to plaque characteristics and clinical outcome J. Cheng
Geen PMID
Relation of Lp(a) with plaque characteris- tics and clinical events: ATHEROREMO and IBIS_3 cohorts S. Vlieger, J. Cheng
Chirurgie
PMID: 39365602
Do large language model chatbots perform better than established patient information resources in answering patient questions? A comparative study on melanoma
J. Kievits, P. Plaisier
PMID: 39827530
Psychological health status after major trauma across different levels of trauma care: A multicentre secondary analysis T. Jakma
PMID: 39908025
Perineal Wound Closure Using Gluteal Turnover Flap After Abdominoperineal Resection for Rectal Cancer: The BIOPEX-2 Randomized Clinical Trial B. Lamme
PMID: 39982377
Risk of lymph node metastasis in pT2 rectal cancer: a nationwide retrospective analysis
B. Lamme
PMID: 40009914
Salvageable locoregional recurrence and stoma rate after local excision of pT1-2 rectal cancer – A nationwide cross-sectional cohort study B. Lamme
PMID: 40044935,
Can we avoid casting for suspected scaphoid fractures? A multicenter randomized controlled trial W. Bosman
PMID: 40212160, Fostering an open surgical culture: strategies to eliminate inappropriate behavior in surgical practice M. Lijkwan
PMID: 40232159
The TESTBREAST journey: Revisiting the importance of early detection by frequent screening of women at high risk of breast cancer
M. Menke-Pluijmers
PMID: 40323649
Stoma Rate and Oncological Outcomes of Primary TaTME Vs Completion TaTME in Patients With Early-Stage Rectal Cancer E. Belt
PMID: 40338310
Higher incidence of trocar site hernia with gallbladder extraction via umbilical versus epigastric trocar port: a multicentre retro- spective analysis of laparoscopic cholecystectomy E. van Bodegraven, B. Schaafsma, R. Smeenk
PMID: 40397270
Suspected Buruli ulcer cases in Tonkolili District, Sierra Leone- a prospective cohort study J. Nunes
PMID: 40498166
Prospective nationwide audit of short-term outcomes after surgery for chronic pilonidal sinus disease in the Netherlands E. Huurman, L. de Raaff, R. van den Berg, R. Smeenk
PMID: 40618991
Aneurysmal Dilated Popliteal Vein Due to a Traumatic Arteriovenous Fistula S. Steunenberg, M. Hoedt
PMID: 41033233
Selection for local treatment and outcomes of surgical resection in patients with synchronous colorectal liver metastases: A nationwide population-based study
E. Belt
PMID: 41067101
Influence of socioeconomic position on surgical outcomes after resection of colorectal liver metastases
E. Belt
PMID: 41249936
Patient preferences for analgesia in lung surgery: an observational cohort study E. von Meyenfeldt
PMID: 41314940
Long-term outcome after liver surgery for colorectal metastases in elderly patients: a nationwide population-based study V. van Woerden, E. Belt
PMID: 41367578
Redefining treatment interval in lung cancer surgery in the era of prehabilitation: a systematic review S. Janki, G. Marres
PMID: 41406011
Using a composite end-point and WIN-ratio analysis to evaluate perineal wound healing after abdominoperineal resection for rectal cancer: further insights from the BIOPEX trials
B. Lamme
Geen PMID
Incidence and prevalence of traumatic and non-traumatic wounds and burns and access to wound care in Sierra Leone; data from a nationwide household survey (PRESSCO) 2020 J. Vas Nunes
Geen PMID
Multicenter, randomized non-inferiority trial comparing TRansanal minimal InvAsive Surgery (TAMIS) and endoscopic Submucosal dIsseCtion (ESD) for resection of non-pedunculated rectal lesions E. Belt
Geen PMID
No #me too please! How to address transgressive behaviour and how to change your workplace towards a culture of accountability
M. Lijkwan
Chirurgie, Longgeneeskunde
PMID: 40147400
Two-year survival and disease recurrence after endosonography with or without confirmatory mediastinoscopy for resectable lung cancer (a short communication of the MEDIASTrial follow-up G. Marres, E. van Thiel
Gynaecologie
PMID: 39591762
Evaluation of the recently established Dutch nationwide Archipelago of Ovarian Cancer Research biobank
A. Makkus, G. Nieuwenhuyzen-de Boer
PMID: 40154162
Genome-wide cell-free DNA methylation profiling in advanced stage ovarian cancer. Are we looking at the tumor or the patient’s immune response to the tumor? G. Nieuwenhuyzen-de Boer
PMID: 40294513
Diagnostic workup of patients with benign or inconclusive reports on office endometrial biopsy after first episode of postmenopausal blood loss G. Nieuwenhuyzen-de Boer
PMID: 40361319
Feasibility and Effects of Implementing Multimodal Prehabilitation Before Cytoreductive Surgery in Patients with Ovarian Cancer: The Gynofit Multicenter Study F. de Kort, G. Nieuwenhuyzen-de Boer
PMID: 40528522
Chorionic Villus Sampling for Rapid Confirmation of High-Risk NIPT Results for Trisomy 21, 18, and 13 S. de Weerd
PMID: 40632662
Improving imiquimod use in cervical highgrade squamous intraepithelial lesions: A qualitative study
G. Nieuwenhuyzen-de Boer
PMID: 40678846
The Introduction of the vNOTES Hysterectomy in The Netherlands: A Nationwide Cohort Study M. van der Vlist
PMID: 40920401
Myo-inositol Supplementation to Prevent Pregnancy Complications in Polycystic Ovary Syndrome: A Randomized Clinical Trial
M. Bandell, S. de Weerd
PMID: 40992929
Residual Risks of Fetal Chromosome Aberrations When Cell-Free DNA Prenatal Screening Is Normal: A Retrospective Study S. de Weerd
PMID: 40996763
Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care: The SUMMER Randomized Clinical Trial M. Bandell
Geen PMID
Adjuvant prophylactic human papillomavirus vaccination for prevention of recurrent high-grade cervical intraepithelial neoplasia lesions in women undergoing lesion surgical treatment (VACCIN): a multicentre, phase 4 randomised placebocontrolled trial in the Netherlands,
G. Nieuwenhuyzen-de Boer
Geen PMID
Multimodal Prehabilitation In Ovarian Cancer Patients Results In Improved Chemotherapy Tolerance: A Multicenter Cohort Study
F. De Kort, G. Nieuwenhuyzen-de Boer
Gynaecologie, Interne geneeskunde
PMID: 39761054
Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes: A Randomized Clinical Trial
B. Akerboom, R. Kiewiet-Kemper
Gynaecologie, Radiologie
PMID: 40420328
Quality of life 1 year after uterine artery embolization vs hysterectomy for symptomatic adenomyosis (QUESTA study) G. van Hoecke, O. Elgersma
Intensieve geneeskunde
PMID: 40444260 Completing Death Certificates in Hospital Setting: What Can Go Wrong, Will Go Wrong R. So
PMID: 40197207
Correction: Standard versus double dosing of beta-lactam antibiotics in critically ill patients with sepsis: The BULLSEYE study protocol for a multicenter randomized controlled trial P. Deetman
Intensieve geneeskunde,
Anesthesiologie
PMID: 41331481
Beta-lactam dose reductions in critically ill patients with acute kidney injury: a scoping review P. Deetman
PMID: 40071336
Routine anaesthesia ward-based patient visits in surgery: 1-year outcomes of the TRACE randomized clinical trial L. Posthuma
PMID: 40989899
The prognostic value of postoperative cardiac troponin I and T for major adverse cardiac events after coronary artery bypass grafting: a systematic review L. Posthuma
Interne geneeskunde
PMID: 40054616
Associations of various medical nutrition therapy strategies with body composition, and physical and clinical outcomes in acute myeloid leukemia patients undergoing intensive remission-induction treatment: a multicenter prospective correlational study C. van Tilborg, P. Westerweel, S. de Zeeuw
PMID: 40249860
Atezolizumab Consolidation in Patients with High Risk Diffuse Large B-cell Lymphoma in Complete Remission after RCHOP
E. de Jongh
PMID: 41134861
Differences in antihypertensive drug blood levels in patients with hypertension (DECISION): A prospective study comparing pharmacokinetics and pharmacodynamics of perindopril in younger and older patients J. van der Net
PMID: 40162636 Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism P. Westerweel
PMID: 41338862
Fixed-duration ibrutinib-venetoclax with MRD-guided ibrutinib-obinutuzumab intensification in first-line chronic lymphocytic leukaemia (HOVON 158/NEXT STEP): primary analysis of a multicentre, openlabel, phase 2 trial M. Levin
PMID: 41358601
Fixed-Duration versus Continuous Treatment for Chronic Lymphocytic Leukemia M. Levin
PMID: 40845265
Frail subgroups determine heterogeneous outcomes in older patients with NDMM long-term follow-up of the HOVON 143 trial
M. Levin
PMID: 41054769
Immune signatures in older patients with newly diagnosed multiple myeloma are associated with survival outcomes of firstline therapy irrespective of frailty levels M. Levin
PMID: 40249856
Long term follow-up of MRD guided treatment of Ibrutinib plus Venetoclax for Relapsed CLL: phase 2 VISION/HO141 trial M. Levin
PMID: 39367118
Midostaurin added to 10-day decitabine, for patients unfit for intensive chemotherapy with AML and higher risk MDS, irrespective of FLT3 mutational status, does not improve outcome P. Westerweel
PMID: 41254114
Nilotinib versus imatinib with early switch from imatinib to nilotinib to obtain treatment-free remission in newly diagnosed chronic myeloid leukemia patients: the analysis of the first co-primary endpoint P. Westerweel
PMID: 40253687
Opportunistic screening for atrial fibrillation among frail older patients, little effort for a high diagnostic yield. Outcomes of the Dutch-GERAF study L. Louter
PMID: 40991848
Prognostic value of premaintenance FDG PET/CT response in patients with newly diagnosed myeloma from the CASSIOPEIA trial M. Levin
PMID: 40741917
PSA Secretion from Single Circulating Tumor Cells of Metastatic CastrationNaïve Prostate Cancer Patients J. van den Bosch
PMID: 40053493
Rationale and design of the Renal Lifecycle trial assessing the effect of dapagliflozin on cardiorenal outcomes in severe chronic kidney disease J. van der Net
PMID: 41041907
Subcutaneous daratumumab plus carfilzomib and dexamethasone (D-Kd) versus carfilzomib and dexamethasone (Kd) in patients with relapsed/refractory multiple myeloma who received previous daratumumab treatment: LYNX study M. Levin
PMID: 39792178
Sustained treatment-free remission in two chronic myeloid leukemia patients after asciminib discontinuation: a report of two cases
A. Yousefi, M. Levin, P. Westerweel
PMID: 39889323
The association between hospital volume and overall survival in adult AML patients treated with intensive chemotherapy M. Levin
PMID: 40864973
The impact of fitness and dose intensity on clinical outcomes with venetoclaxobinutuzumab in CLL
M. Levin
PMID: 40936723
The prognostic value of health-related quality of life for early molecular response in patients with chronic myeloid leukemia: analysis of the GIMEMA-SUSTRENIM trial P. Westerweel
PMID: 40384450
The ‘Stop TPO-RA in ITP Patients’ study: Clinical and immune modulatory effects of romiplostim tapering P. Westerweel
PMID: 39762207
Treatment with obinutuzumab plus venetoclax reshapes the TRB repertoire of CLL patients
P. Hengeveld, P. Westerweel, M. Levin
PMID: 39957332
Treatment-Free Remission Outcomes in a BCR::ABL1 Digital PCR Selected Clinical Cohort of CML Patients C. Kockerols, M. Levin, E. de Jongh, R. Blommers, P. Westerweel
PMID: 41368074
Uncovering the ultra-frail: A distinct subgroup in non-transplant eligible newly diagnosed patients with multiple myeloma, with an inferior clinical outcome M. Levin
PMID: 40963393
Venetoclax plus hypomethylating agents as a bridge to transplant or donor lymphocyte infusion in relapsed/refractory acute myeloid leukemia E. de Jongh
Kindergeneeskunde
PMID: 38952118
IGF1 Haploinsufficiency: Phenotype and Response to Growth Hormone Treatment in 9 Patients J. Renes
PMID: 40424589
Clinical Characteristics and Response to Growth Hormone Treatment in 27 Children With Heterozygous NPR2 Variants: Real-World Data
- J. Renes
PMID: 38838660
Effects and Safety of Growth Hormone Treatment in Six Children with Pycnodysostosis
- J. Renes
PMID: 41077274
Expansion of the phenotype in ZFX neurodevelopmental disorder in a family M. de Jong
PMID: 40621613
Growth hormone treatment adjusted for growth hormone sensitivity in idiopathic short stature J. Renes
PMID: 41092582
Pediatric enteral nutrition after hospital discharge: A systematic review and toolbox for clinical practice A. Lebon
PMID: 40828532
Risk Factors for Severe Pediatric Invasive Group A Streptococcal Disease A. Lebon
PMID: 41347528
Trends in asthma exacerbations in children before, during and after the COVID19 pandemic
L. Stadhouders, E. Hoogteijling, A. Lebon
Klinische Chemie
Geen PMID
Red blood cell properties in hereditary xerocytosis and their response to ex vivo pyruvate kinase activation: a preliminary study J. Riedl
Z
was
Longgeneeskunde
PMID: 41286740
Acute home-based management initiatives for COVID-19 patients needing oxygen: observational study reporting mortality and hospital admission outcomes
E. van Thiel, N. de Graaf
PMID: 40636057
Health outcomes up to 3 years and postexertional malaise in patients after hospitalization for COVID-19: a multicentre prospective cohort study (CO-FLOW) W. Blox
Longgeneeskunde, Intensieve geneeskunde
PMID: 39941539
The Effects of Home High-Flow Nasal Cannula Oxygen Therapy on Clinical Outcomes in Patients with Severe COPD and Frequent Exacerbations C. Theunisse, N. de Graaf, H. Ponssen, D. Cheung
Maag-, darm en levergeneeskunde
PMID: 39624922
Early HBcrAg and Anti-HBc Levels Identify Patients at High Risk for Severe Flares After Nucleos(t)ide Analogue Cessation-A Pooled Analysis of Two Clinical Trials P. Honkoop
PMID: 39999021
The Association Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Change in Liver Stiffness in Patients With Chronic Hepatitis B P. Honkoop
PMID: 40244344
Evaluation of an Exercise Program in Patients with Inflammatory Bowel Disease: A Pilot Study V. de Jonge
PMID: 40345412
CT-colonography in Fecal Immunochemical Test Positives in a Colorectal Cancer Screening Program L. Wolters
PMID: 40530613
Small and Stable Pancreatic Cysts Are Reassuring During Surveillance: Results From the PACYFIC Trial P. Honkoop
PMID: 40753475
Patients’ Attitude toward Less Frequent Surveillance of Low-Risk Pancreatic Cysts: A Multicenter European Cohort Study P. Honkoop
PMID: 40838198
Circulating tumour cells & circulating tumour DNA in patients with resectable colorectal liver metastases (MIRACLE): a prospective, observational biomarker study E. Belt
PMID: 40912695
Identification of robust associations between admission microbiome profiles and complications of acute pancreatitis W. van de Vrie
PMID: 40922677
Prediction of Hepatocellular Carcinoma and Other Liver-Related Events in Chronic Hepatitis B Patients With Metabolic Dysfunction or Metabolic Dysfunction-Associated Steatotic Liver Disease P. Honkoop
PMID: 41125366
Adherence to a care pathway for inflammatory bowel disease in the southwest region of the Netherlands: results of a mixedmethods implementation study V. de Jonge
PMID: 41143239
Persistent risk of hepatocellular carcinoma despite improvement of liver stiffness in patients with chronic HBV with advanced fibrosis
P. Honkoop
Geen PMID
Acetic acid chromoendoscopy for the detection of neoplastic Barrett Esophagus: a stepped wedge cluster randomized clinical trial
W. van de Vrie
Geen PMID
Long-term results of a prospective study comparing lumen-apposing metal stents versus double-pigtail plastic stents for infected necrotizing pancreatitis P. Honkoop
Medische microbiologie
PMID: 40184501
Epidemiological and clinical insights into enterovirus circulation in Europe, 2018 2023: a multi-center retrospective surveillance study E. Huijskens
PMID: 40215651
Sustained circulation of enterovirus D68 in Europe in 2023 and the continued evolution of enterovirus D68 B3-lineages associated with distinct amino acid substitutions in VP1 protein
E. Huijskens
PMID: 40339920
The use of a Poisson hidden Markov model for automated detection of hospital outbreaks with vancomycin-resistant enterococci in routine surveillance data B. Maraha
Medische psychologie
PMID: 40132436
The burden of depression among patients with type 2 diabetes: An umbrella review of systematic reviews F. van Hasselt
Neurologie
PMID: 39127910
Prehospital stroke detection scales: A head-to-head comparison of 7 scales in patients with suspected stroke H. Kerkhoff
PMID: 39874354
The liminal space between hope and grief: The phenomenon of uncertainty as experienced by people living with relapsing-remitting multiple sclerosis J. de Beukelaar
PMID: 39907163
Multifaceted Biomarkers Suggest a Similar Profile of CNS Pathology in Relapsing and Progressive MS
K. Blok, R. Klein Kranenbarg, J. de Beukelaar
PMID: 40083553
The gut-brain-axis one year after treatment with cladribine tablets in patients with relapsing remitting multiple sclerosis: a pilot study
J. de Beukelaar
PMID: 40084606
If it does not help, it might hurt: Pharmacodynamics of a second IVIg course in Guillain-Barré syndrome
K. Kuitwaard
PMID: 40096525
Large-scale profiling of antibody reactivity to glycolipids in patients with Guillain-Barré syndrome K. Kuitwaard
PMID: 40198869
Prehospital Large-Vessel Occlusion Stroke Detection Scales: A Pooled Individual Patient Data Analysis of 2 Prospective Cohorts
M. Duvekot, H. Kerkhoff
PMID: 40227717
Risk of Poststroke Epilepsy Among Young Adults With Ischemic Stroke or Intracerebral Hemorrhage H. Kerkhoff
